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Increased levels of these metabolites are associated with increased expression of VCAM-1, and increased leukocyte adherence to vascular endothelium in mice, suggesting that an inflammation-dependent mechanism may underly the association of these metabolites with the development of major CV adverse events (Ferrell et al, 2024)

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Research applications focus on synergistic activation of the GH axis, receptor interaction, and controlled GH pulse dynamics in laboratory models