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Moreover, an inefficient immune system may favour viral persistence (321), or reactivation of latent viruses, whereas an overreactive immune system may lead to an excessive inflammation (89)

Extracellular HMGB1 as a proinflammatory cytokine

6 Therapeutic limitations Natural antioxidant agents have many modes of action and can be useful in preventing diseases without side effects (Chaudhary and Janmeda, 2022b)