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This inflammatory process includes microglial activation, increased cytokine release, and increased oxidative stress, as well as changes in glutamatergic system regulation that may exacerbate astrocyte atrophy and local damage following these events (48)

Annu Rev Pharmacol Toxicol 2005

Hydroxytyrosl is also reported to induce Nrf2 in PI3K dependent manner (Martn et al., 2010)

Melatonin suppresses ferroptosis induced by high glucose via activation of the Nrf2/HO-1 signaling pathway in Type 2 diabetic osteoporosis

Taking them late at night may, for some individuals, lead to a feeling of alertness that could interfere with winding down for sleep