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39 BE ON THE LOOKOUT Biologic medications are becoming critical in medicine, for treating conditions ranging from autoimmune diseases to metastatic cancers

In this Primer, we provide an overview of the synthesis of macrocyclic CB[ n ], functionalized CB[ n ] and acyclic CB[ n ]-type receptors

More generally, GSNO is a major source of NO bioactivity in the brain and its depletion will inhibit the activity of GSNOR resulting in increased nitrosylation (nitrosative stress) (36, 37) and possibly altered neurotransmission

Most dosing is done in the evening, before sleep onset, because the aim is to induce sleep or promote deep sleep