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348 Similarly, in human chondrocytes stimulated by TNF, GLP-1 analogs (such as liraglutide) showed an anti-catabolic effect, reducing the mRNA expression of MMP-3, MMP-13, and ADAMTS5

As derived in Tielker et al

NAD + functions as a metabolic driver of circadian transcription via epigenetic mechanisms, transducing signals originated by environmental stimuli to the circadian clock

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