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The enrichment process during sample preparation means the resultant higher multiple testing during spectral identification is outweighed by the decreased complexity of the input sample, and the elimination of most full-length proteins from analysis 19

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Tchang BG, Aras M, Wu A, et al

The answer depends on the treatment goal, delivery method, comfort level, medical history, and provider guidance

In order to select the appropriate model, we employed an objective function comprised of specificity values, the proportion of true negatives identified within decoys excluded from training, the percentage of active compounds identified from the family, and the percentage of compounds from the binding database not associated with the family, then we established an ML model for each family, as delineated in Table 4