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Metabolism and Bioavailability of Glucosinolates Metabolism The hydrolysis of glucosinolates, which is catalyzed by a class of enzymes called myrosinases (-thioglucosidases), leads to the formation of breakdown compounds, such as thiocyanates, isothiocyanates, indoles, oxazolidine-2-thiones (e.g., goitrin), epithionitrile, and nitrile ( Figure 2 )

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These effects were generally mild and transient

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Nevertheless, it can also behave as a pro-oxidant by increasing the level of hydrogen peroxide (H 2 O 2 ) which is the main component of oxidative stress and apoptosis in cancer cells

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Simabuco, A.D

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doi: 10.1159/000503866 264 DasRSenguptaTRoySChattarjiSRayJ

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