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The basic idea involves a linkage of a nuclear hormone to a peptide, usually through a linker that would allow metabolism of the nuclear hormone only within the targeted cell reducing the undesirable effects in other tissues

[PMID:20106400] Lin KH, Huang YJ, Hsu HH, et al

Elevated levels of fibrinogen, PAI-1, thrombin, von Willebrand factor, factor VII, and other coagulation factors, as well as significant platelet aggregation, define it (147)

Other parts might have virtually no preservative at all, rendering them no better than sterile water and susceptible to bacterial growth

Theyre also more likely to leave a whitish cast, particularly on the darkest and the fairest skin tones