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"PT-141: a melanocortin agonist for the treatment of sexual dysfunction." Annals of the New York Academy of Sciences 2003;994:96-102

Later, oxLDL (338) and MDA-LDL (248) were shown to compete with AcLDL for binding and uptake by macrophages, suggesting they were native ligands for MSR

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In the context of the association between neuroinflammatory conditions and metabolic syndrome/type II diabetes (in which glutamate may pay a key role) , Stanford researchers (Winer et al, 2011) have demonstrated the effectiveness of Rituximab treatment in mice in an autoimmune model of type II diabetes : B cell effects on glucose metabolism are mechanistically linked to the activation of proinflammatory macrophages and T cells and to the production of pathogenic IgG antibodies