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162,163,164 There is evidence that ROS engages in inflammasome activation in multiple tissues

Characterized by lipid peroxidation and abnormal iron accumulation, ferroptosis has attracted significant attention due to its unique association with pathological conditions such as ischemia-reperfusion injury, neurodegeneration, and cancer [2,3,4]

Activation of caspase-1 by inflammasomes induces pyroptosis, an inflammatory form of programmed cell death (Wroska et al., 2024)

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5.1.1 M1 macrophages Upon encountering allergens or pollutants, macrophages often polarize toward a pro-inflammatory M1 phenotype