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Further update and validation of the model are needed for patients treated in the late time window (6-24h)

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The latest study by the same group suggests that this effect may result from Mn impairing lysosomal protein degradation (Rokad et al., 2024)

International Journal for Vitamin and Nutrition Research 77(1):4145 Chander H, Sharma G (2020) Some rare ethnomedicinal plants of lower foot hills of North-Western Himalaya in Himachal Pradesh

For instance, IPA specifically binds to methionine adenosyltransferase 2A (MAT2A), enhancing S-adenosylmethionine synthesis and subsequently inducing DNA methylation of the deubiquitinating enzyme USP16