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The highest reported oral dose of GABA involved 14 adults (8 gram/kg/day divided into 4 doses) for up to 2 years and was well-tolerated (146)

This is because contractile activities alter the redox status in muscles toward a more oxidative state, leading to a lowered mitochondrial NADH/NAD + ratio

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This not only leads to a significant increase in ROS generation but also further amplifies the local inflammatory response by releasing pro-inflammatory signals (81)