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Long-term effects of repeated cycles have not been mapped in published Western trials

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doi: 10.1016/j.stem.2021.08.007 221 JohnsonAMBullockBLNeuweltAJPoczobuttJMKasparRELiHYet al

An excess of I can increase the antigenicity of Tg, stimulate the production of cytokines and chemokines, which can increase the accumulation of immunocompetent cells in the thyroid gland, increase the level of OS in thyrocytes, stimulate lipid peroxidation and damage to thyroid tissue ( In regions with excessive consumption of I, there is an increased frequency of AIT characterized by high titers of TPOAb and TgAb ( However, in HT patients from an iodine-deficient region of Turkey, no association was found between HT and urinary I levels, which were not elevated compared to the general population