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Luzindole (LUZ) is a widely used non-selective antagonist of the melatonin receptors MT1 and MT2, enabling us to test whether the effects of exogenous melatonin were receptor-mediated ( Figure 2 Using the same multi-parameter approach applied to the AA model, we evaluated disease outcomes in IL-33 challenged mice in the presence or absence of melatonin and Luzindole

Conversely, since long-term neurotoxicity is believed to be mediated by metabolites formed after methylenedioxyphenyl ring-opening by CYP2D6 (de la Torre and Farr, 2004

If possible, multicenter clinical trials should be conducted in as many regions as possible

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