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One study found people with obesity who had higher levels of glutathione lost more weight when they followed a healthy eating plan for 6 months

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On the other hand, IL-1 can feedback-stimulate NADPH oxidase, further exacerbating oxidative stress ( 3.2 Oxidative stress and metabolic dysregulation Mitochondrial dysfunction mediated by the SIRT1/NAD + pathway represents a pivotal mechanism in DN pathogenesis, where oxidative stress emerges as a central driver

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