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Consistently, some of the most down-regulated GO terms concerning Cellular Component were: synapses, neuron projection, microtubule cytoskeleton, Golgi apparatus and ER (Fig

Both genetic ablation of PAAN/MIF and the nuclease-deficient mutant have been demonstrated to protect against dopaminergic neuron loss and mitigate behavioral impairments in the -syn preformed fibril mouse model of sporadic PD ( Epigenetic mechanisms, including DNA methylation, histone modifications and non-coding RNA regulation, play significant roles in modulating dopamine transporter (DAT) endocytosis, a process implicated in PD pathogenesis (Su and Liu, 2017)

Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours

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