Studies show using moisturizers rich in folic acid led to increased hydration of the skin
Abbreviations AA: Arachidonic acid ATF6: Activating transcription factor-6 CHOP: C/EBP homologous protein CIH: Chronic intermittent hypoxia CVD: Cardiovascular disease CYPs: Cytochromes P450 DG: Diacylglycerol DGATs: Diacylglycerol acyltransferases DHA: Docosahexaenoic acid DNL: De novo lipogenesis DPA: Docosapentaenoic acid EPA: Eicosapentaenoic acid ER: Endoplasmic reticulum FAO: Fatty acid oxidation FAT/CD36: Fatty acid translocase FATPs: Fatty acid transport proteins FFAs: Free fatty acids GPL: Glycerophospholipid GRP78: Glucose-regulated protein 78/immunoglobulin-heavy-chain-binding protein GSDMD: Gasdermin D HIFs: Hypoxia-inducible factors IR: Insulin resistance IRE1: Inositol-requiring kinase 1 JNKs: c-Jun N-terminal kinases LAL: Lysosomal acid lipase LDL: Low-density lipoprotein LPL: Lipoprotein lipase LPS: Lipopolysaccharides LyPC: Lysophosphatidylcholine MAFLD: Metabolic associated fatty liver disease MLKL: Mixed lineage kinase domain-like NAFL: Non-alcoholic fatty liver NAFLD: Non-alcoholic fatty liver disease NASH: Non-alcoholic steatohepatitis NLRP3: NACHT, LRR and PYD domains-containing protein 3 OSAS: Obstructive sleep apnea syndrome PC: Phosphatidylcholine PE: Phosphatidylethanolamine PERK: Double-stranded RNA-dependent protein kinase-like ER kinase PI: Phosphatidylinositol PUMA: p53 upregulated modulator of apoptosis RIP: Receptor-interacting protein ROS: Reactive oxygen species SREBPs: Sterol regulatory element binding proteins SERCA2: Sarco/endoplasmic reticulum Ca 2+ -ATPase 2 TGs: Triglycerides TRAIL: TNF-related apoptosis-inducing ligand UPR: Unfolded protein response VLDL: Very-low-density-lipoprotein WAT: White adipose tissue References Eslam M, et al
Learn more about Hamamelis Virginiana Leaf Water Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging
Avoid other skin irritants: While using Tretinoin/Niacinamide Cream, refrain from using other potentially irritating skincare products, such as abrasive cleansers, harsh exfoliants, or products containing alcohol
Anti-inflammatory effects Through modulation of inflammatory mediators, ozone reduces prostaglandin synthesis and decreases joint oxidative stress
