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Clinical Applications of Half-Life Drug accumulation is similar in time course to the time course of drug elimination

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Moreover, microsomal metabolism studies demonstrated that Dihexa had very low phase I metabolism, with an average intrinsic clearance of 2.72 l/min/mg and a half-life of 509.4 minutes

The patient received further phenobarbital doses every 812 h over the next 36 h

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