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Metabolism of testosterone and action of metabolites on prostate glands grown in organ culture

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KAT8-deficient embryos cannot develop beyond the expanded blastocyst stage and die at implantation with a specific loss of H4K16ac [53,54] , indicating that KAT8 is functionally nonredundant with other MYST family of KATs and essential for maintaining H4K16ac and normal chromatin architecture in both male and female embryos

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