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This presents a challenge for those who follow a vegan and vegetarian way of eating, placing them at risk of Vitamin B12 deficiency

It is likely that many patients will require intramuscular B12 replacement for the duration of their metformin treatment, although a trial of oral replacement initially may be worthwhile.

Nasal administration is not well studied, 1 and the difference in effect on B12 levels amongst individuals may be due to the route of administration

Rows in the heat map were split by the average RNA-seq RPKM values in all samples