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[DOI] [PMC free article] [PubMed] [Google Scholar] 37.Tangney C.C., Tang Y., Evans D.A., Morris M.C

Application of this assay to analyze plasma from patients with known oxidative stress (sickle cell disease and sepsis) and from a patient with sickle cell disease treated with the antioxidant N-acetylcysteine suggests that cysteine disulfides, in particular protein-bound cysteine, serve as sensitive plasma biomarkers for the extent of oxidative stress and effectiveness of antioxidant treatment