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The accumulation of -syn into prefibrillar forms, and then its assembly into higher molecular weight aggregates, induces cellular toxicity and maybe the greatest contributor to pathogenesis in PD (Bengoa-Vergniory et al., Figure 1 Synaptic Vesicle Impairment -syn is typically localized to the presynaptic terminal where it associates with synaptic vesicles and influences membrane curvature (Maroteaux et al., 1988

(2010) Journal of Molecular Endocrinology

Furthermore, it has been found in humans and animals that nicotine enhances the learning ability (Poorthuis et al., 2009), improves neuronal plasticity in the hippocampus (Motaghinejad et al., 2016), and can treat excitotoxicity at low concentrations (Sieber, 2012)

4 However, most patients will experience symptoms of longer than 2 weeks