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Liker et al

NNMT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to nicotinamide, influencing intracellular nicotinamide availability and interacting with NAD-associated metabolic processes

Cyclic nucleotides may mediate taste transduction

As concerns treatment of T!D, longer acting preparations of GABA, co-therapy with GABA receptor agonists, positive allosteric modifiers (59) or complimentary antidiabetic agents (discussed above) could potentially overcome a need for higher GABA doses to achieve efficacy