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10.1126/science.aba5257 Science 57 KwokT.ZablerD.UrmanS.RohdeM.HartigR.WesslerS.et al (2007)

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The nucleophile penicillamine is able to ameliorate the impact of acute treatment with H 2 O 2 on oocytes Taken together, our data raise the intriguing prospect that the structural perturbation of tubulin that is induced by 4-HNE adduction may, at least in part, contribute to increased aneuploidy rates observed in oocytes exposed to elevated levels of OS

This conversion is a critical step in the folate cycle [Figure 1], with 5-methyl-THF subsequently serving as a substrate for the methylation of homocysteine (Hcy) to methionine (Met)

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