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Description

These mutations carried out the conversion of a proto-oncogene into a carcinogenic oncogene, which is responsible for different types of cancer (Marnett, 2000)

Analysis of the crystal structures of EcGGT, HpGGT, BsGGT, and BlGGT in complex with glutamate demonstrated that the catalytic pocket is enclosed within the shallow groove at the interface of both large and small subunits (Okada et al., 2006