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What Are MTHFR Mutations

doi:10.1124/jpet.104.080275

Common symptoms include: Weight loss or failure to gain (especially in puppies) Chronic diarrhoea or soft stools Lethargy and general weakness Inappetence or fussy eating Intermittent vomiting Flatulence or digestive discomfort Poor coat condition or dull fur Neurological signs (e.g., tremors, confusion, ataxia) Low folate or folate imbalance on bloodwork In puppies or young dogs with genetic B12 absorption issues, growth may be stunted , and immune function may be compromised

Chronic low-grade inflammation can accelerate endothelial dysfunction, increase oxidative stress, attract immune cells to the vessel wall, and contribute to plaque progression and vulnerability

[Google Scholar] Figlin 2003 Figlin E, Chetrit A, Shahar A, Shpilberg O, Zivelin A, Rosenberg N, et al