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In contrast, tofacitinib was associated with more significant elevations in liver function tests, highlighting apremilasts relatively favorable hepatic safety profile (Jadhav et al

A detailed medical history is taken and used to map the sequence of events leading to illness, including potential triggers, predisposing factors, and ongoing drivers

This provided direct evidence of increased lipid peroxidation in the CF airway and strongly suggested that this elevation is a consequence of the pulmonary inflammation characteristic of CF, rather than a direct, inflammation-independent outcome of the primary CF defect

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