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Overall, our results propose a novel therapeutic strategy for APAP-induced liver injury, involving hepsin administration alongside a low dose of NAC to improve treatment effectiveness and address current limitations

Reviews of the rodent work note that the mechanism doesnt involve the hormonal suppression or receptor desensitization that would predict tolerance or rebound, and that adipose SAM levels tend to normalize rather than crash under inhibition

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doi: 10.1515/CCLM.2003.032 249 Decreased consumption of corticosteroids after selenium supplementation in corticoid-dependent asthmatics