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Under conventional physiological circumstances, insulin inhibits lipolysis, which is the degradation of triglycerides into free fatty acids (FFAs) and glycerol in adipose tissue

IUBMB Life 67:659667 Maubant S, Tesson B, Maire V, Ye M, Rigaill G, Gentien D, Cruzalegui F, Tucker GC, Roman-Roman S, Dubois T (2015) Transcriptome analysis of Wnt3a-treated triple-negative breast cancer cells

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In cell-based and animal studies, GHRH-receptor agonism (tesamorelin) and GHS-R1a agonism (ipamorelin) have been reported to engage different intracellular signaling cascades that both terminate in growth-hormone secretion, an arrangement investigators have explored for potentially amplified, rather than simply additive, secretory responses