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Human studies have shown dose-limiting toxicities with NAMPT inhibitors, including gastrointestinal, hematologic, and metabolic effects. Animal studies also demonstrate harm to normal tissues when NAD+ production is reduced. These findings highlight a key challenge: targeting NAD+ metabolism in cancer is difficult because lowering NAD+ can harm healthy cells as much asor more thancancer cells

E., Giustarini, D., Rossi, R., Dela, F., Helge, J

Gradually increasing within standard ranges may help

173 PavlL.BorvkaL.DrbekO.NikodemA

TWIST family of basic helix-loop-helix transcription factors mediate human mesenchymal stem cell growth and commitment