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10.1016/j.jstrokecerebrovasdis.2006.03.002

This target is based on the observation that adverse outcomes were associated with ESA use with hemoglobin targets higher than 13 g/dL ( Table 1 )

Introduction Amino acid metabolism is altered in many cancers, reflecting cancer cell uptake and altered metabolic needs, and targeting these pathways is becoming an attractive approach to patient therapy ( de novo or recycled through protein degradation ( de novo biosynthesis or a catabolic supply of cysteine is not sufficient to meet the high demand for antioxidant synthesis

The S-targeting mAbs included both neutralizing and non-neutralizing molecules which displayed high, yet differential, activity in multiple antibody effector assays dependent on the antigenic target, suggesting a role for the Fv in facilitating both neutralization and Fc effector functions as all isolated mAbs were cloned into the same rh-IgG1 backbone

Horowitz M,