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[DOI] [PMC free article] [PubMed] [Google Scholar] 127.CHANCE B & WILLIAMS GR The respiratory chain and oxidative phosphorylation

Currently, it is unclear if these endogenous and exogenous factors reported in some individuals with ASD contribute to secondary mitochondrial dysfunction or ASD symptoms, or if these factors are merely epiphenomena

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But most studies that report poor tolerance started subjects at doses two to three times higher than necessary