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After reading your experience,and the poor women who took her own life ..and watching how my own mother has been over the last three years..it's a wonder many more people haven't lost their battle, I'm very grateful to the people who took the time to respond to my post , it's got me through a very tough weekend ..and saved me a ton of time researching to find out what the next best move is ..and also it's made me feel less isolated, so I can take a deep breath and start over with a degree of hope in making mums life liveable again J Hello Joseph : Your Mum's dose of T4 needs reinstating and possibly even increasing again : We generally feel best with a TSH under 2 likely under 1 and low in the range - Mum's is currently 4 times over the maximum top end of the range detailed