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FIGURE 3 Effects of GlyNAC Supplementation on GSH Status The primary endpoint of the study was defined as the difference in GSH-T normalized to hematocrit compared to placebo at the end of the study

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While the role of itaconate in limiting inflammation has been studied in peripheral macrophages, its immunometabolic function remains unexplored in HIV and cocaine-exposed microglia

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Targeting lipid metabolic pathways through nutritional modification or adjunctive therapies may complement existing pharmacological and psychosocial treatments, particularly for disorders characterized by metabolic and inflammatory dysregulation