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They found that the intestinal flora differed significantly from that of controls

As illustrated in Supplementary Figure 2B, also the coupling efficiency deteriorates in the presence of oxidative stress

The authors proposed the following model of Se uptake to the brain via SELENOP-LRP8: SELENOP present in blood and CSF is taken up by LRP8-positive cells of BBB and BCB, resynthesized in neighboring astrocytes, and subsequently released to supply LRP8-positive neurons within the brain with Se Figure 2