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10.1089/ars.2016.6925 76 RheeS

In fact, one clinical study comparing the same amount of B-12 given orally or under the tongue found they were equally effective at correcting B-12 deficiency over a two-month period

Isakson, S

In RA, a five-fold increase in the production of mitochondrial ROS was reported, so it has been shown that oxidative stress is a hallmark of this disease [11,12,13]