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For researchers exploring alternatives to gavage, encapsulation remains the most reliable method to balance stress reduction, dose certainty, and taste elimination, provided the delayed absorption window is compatible with behavioral testing schedules

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In sum, ctDCS responsiveness appears intrinsically state-dependent: the neurochemical milieu, inflammatory activity, and genetic background gate both the sign and magnitude of induced plasticity, offering a coherent explanation for the between- and within-subject heterogeneity observed to date

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