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The specific historical details in the opening paragraphs, including the 1975 origin, the second-year medical school account, and the name Substancija Boe Pomozi, are the product of that original reporting rather than established common knowledge

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In contrast, drugs that are inhibitors of cytochrome P450 isozymes, e.g., antidepressants, may be expected to have little effect on valproate clearance because cytochrome P450 microsomal mediated oxidation is a relatively minor secondary metabolic pathway compared to glucuronidation and beta-oxidation

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