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The WHI used synthetic conjugated equine estrogens plus medroxyprogesterone acetate in women who were on average 63 years old over a decade past menopause

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10.1161/JAHA.113.000519 63

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Nature 419 , 9094 (2002)

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However, lixisenatide in the ELIXA trial did not significantly alter the incidence of MACE, and exnatide in the EXSCEL trial lower the risk of MACE with no significant difference

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[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Takahashi M, Ueda S, Misaki H, Sugiyama N, Matsumoto K, Matsuo N, Murao S

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