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Most practitioners prefer the no DAC version because its more physiologic and allows easier dose adjustment

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Therefore, it is speculated to be a multi-factorial disorder, involving epigenetics, genetics and environmental factors

To calculate relative miR-4488 quantities, miR-4488/SNORD44 ratio in the input samples was used to divide miR-4488/SNORD44 ratios derived from the pulled-down samples in order to normalize and correct for all possible technical anomalies