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Estrogen plays a key role in bone and muscle health, and as it drops, bone density and muscle mass can take a hit, says Ramallo

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At 0.25mg doses where you are drawing tiny volumes, waste as a percentage is relatively small

While a bone marrow biopsy was not conducted in this instance, it is generally not required for diagnosing vitamin B12 deficiency unless there is a concern for hematologic malignancies