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If any step of the process is disrupted, the activity of GPX4 will decrease, resulting in the accumulation of intracellular peroxides, which contributes to ferroptosis

As a consequence, H

Oncogene 34 , 56175625 (2015)

Interestingly, the overall levels of nucleotides, CTP and TTP were significantly increased, up to 3-fold in HIF1 KO cells, in line with enhanced synthesis (Fig