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The corona includes both opsonins (e.g., IgG, C3b, fibrinogen), which promote clearance by the mononuclear phagocyte system (MPS) and dysopsonins (e.g., albumin, clusterin, apolipoproteins), which help evade immune detection and enhance circulation time [254, 255]

Selenium must be present in an appropriate quantity since both deficit and accumulation may induce health problems such as cardiovascular and metabolism diseases, that appear since selenium is related with metabolic pathways and it has also an antioxidant response

doi: 10.3390/cells9112447 259 WangHZhouYXuHWangXZhangYShangRet al

Asimismo, deber ensearte la forma de llevar a cabo la inyeccin, o a la persona que vaya a aplicrtela