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Key Takeaways Vitamin C is the frontline antioxidant that also recycles glutathione

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Extracellular matrix remodeling in tumor progression and immune escape: From mechanisms to treatments

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Taken together, these findings clearly show that physical cues from the environment can strongly influence the phenotype of tissue-resident fibroblasts, which in turn can shape tissue homeostasis

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The decreased malate/pyruvate and GSH levels with LbNOX expression strongly suggest a decreased cytoplasmic (free) [NADPH]/[NADP + ], while the large increase in pyruvate also strongly suggests that the pyruvate/lactate, a proxy for the cytoplasmic (free) [NAD + ]/[NADH], increased, which likely drove the lifespan extension in the females

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Its important to understand these risks for safe use

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