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BCRP has been found to be associated with c-MET/PI3K and JNK1 Signaling pathways in multidrug-resistant CRC (40, 42)

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Additionally, TFAs induce endoplasmic reticulum stress and impair autophagy, contributing to insulin resistance, hepatic steatosis, and adipose tissue dysfunction

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Could abstinence from CSI have reduced the risk of such a downward spiral

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