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Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced Ferroptosis in head and neck cancer

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Although our findings primarily focus on the anti-inflammatory impact of Irisin on microglia and dopaminergic neurons, we recognize the potential significance of astrocyte modulation in Irisins protective mechanisms

For example, in high grade glioma, a Cochrane Review concluded that anti-angiogenic drugs do not improve significantly overall survival and there are no evidences to support this therapeutic approach [19]

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