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Clinical trials are also challenged by the variability of biomarkers including autophagy-related gene expression, lysosomal activity, and non-coding RNA regulation that remain insufficiently standardized for predicting treatment response

[DOI] [PMC free article] [PubMed] [Google Scholar] Shimizu Y

Next, the MINE authors explained their scoring system: "The severity class was assigned based on the total score obtained from the summation of the single scores attained by each of the 4 echocardiographic variables (Table 2)." They found that a MINE score above 8 (the lowest total score for the "severe" classification) was predictive of MVD being the cause of the dog's death

Arch Intern Med 2010

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