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Nat Commun (2020) 11(1):4997

doi: 10.1038/s41374-021-00652-z 150 PehHYTanWSDChanTKPowCWFosterPSWongWSF

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Similarly, supplementation with daidzein was shown to reduce the level of myeloperoxidase MPO and inhibit the expression of TNF-, IL-1, and IL-6, in the colonic tissues, inhibiting the production of NO and prostaglandin E2 in LPS-stimulated RAW 264.7 macrophages [189]

12.2.2 Potential antagonistic effects Conversely, curcumin has been shown to interfere with the action of other chemotherapeutic drugs (e.g., cyclophosphamide, doxorubicin) by activating certain detoxification pathways (like ABC transporters) that pump the drugs out of cancer cells, thereby reducing their effectiveness (244)