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At the anterior pole, BMAL1 labelling was mainly detected in the epithelium, with less labelling evident in the fiber cells for each time point ( Figures 5AD )

Recent studies have revealed that MERCs play a role in the regulation of cell division, and HMOX2 has been identified as an iron source for cell proliferation 22,46

For instance, researchers have experimented with CAR-T cells overexpressing PGC-1 (the transcriptional coactivator that drives mitochondrial biogenesis)

The role of the immune system in cutaneous squamous cell carcinoma

This leads to disruptions in the transcription of proteins vital to the mitochondrial ETC, thus inducing malfunction and hindering ATP synthesis, which in turn might escalate ROS generation [113]