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Radiat Oncol (2014) 9(1):88

Consider a series of treatments rather than a single session for persistent symptoms, as cumulative benefits often provide more sustainable improvements

Regardless, the proportional degree by which apoptosis, ferroptosis, pyroptosis, or other processes are responsible for IR-induced cell death remains an intriguing area for future research

For example, increased arginase activity enhances polyamine synthesis while limiting nitric oxide production, shifting the balance between proliferative and immunomodulatory outputs

AMPKSIRT1PGC-1 axis activation has been shown to enhance mitochondrial efficiency, reduce ROS generation, and maintain energy homeostasis within aging oocytes (39, 40)